Parkinsonism

Disease modifying treatment available:
Time critical diagnosis and management:
Lateralising:

Aetiology

Exercise, ibuprofen use and coffee consumption are all associated with a lower risk of Parkinson's disease.

Disorder Clinical features Associated features Investigations Disease modifying treatment available Time critical
Huntington's disease Chorea
Dementia
Motor impersistence
Parkinson's disease Micrographia
Hyponosmia
 Insomnia
Progressive supranuclear palsy
Multiple systems atrophy
Corticobasal degeneration Corticobasal syndrome
Lewy body dementia Dementia
Hallucination
Vascular parkinsonism
Intracranial mass

Causative drugs






Clinical features


Parkinsonism may cause the following:




Investigations


The role of neuroimaging in the diagnosis of idiopathic Parkinson's disease is sometimes contested. There is a school of thought that in patients with classical presentations neuroimaging is generally non-contributory. Parkinsonism can be caused by structural deficits though which may be apparent on MRI. Cardiac sympathetic denervation on metaiodobenzylguanidine (MIBG) scintigraphy - not very useful? SPECT?


Laboratory Investigation Result

Treatment


Idiopathic Parkinson's disease generally responds well to levodopa. Dopamine-induced dyskinesias are reported to be more common when managing idiopathic Parkinson's disease than in other parkinson plus syndromes and can be used to support diagnosis.