Parkinson's disease

Disease modifying treatment available:
Time critical diagnosis and management:
Lateralising:

Aetiology

Associated genes

Gene
LRRK2 Search ClinVar Search ClinGen
PINK1 Search ClinVar Search ClinGen
SNCA Search ClinVar Search ClinGen


Associated Disorders




Clinical features


The classical resting tremor at 4-6Hz is seen in around 80% of patients and is classically asymmetric at presentation.

Parkinson's disease may cause the following:




Investigations


A significant amount of resources are being invested attempting to identify novel biomarkers for Parkinson's disease. One recent example is a blood-based α-synuclein (α-syn) seed amplification assay (SAA) which has been reported to successfully detect the disease years before the onset of neurological symptoms.


Laboratory Investigation Result