Disease modifying treatment available:
Time critical diagnosis and management:
Lateralising:
| Subclassifications | Epidemiology | Clinical features |
|---|---|---|
| Dementia | None | Cerebrotendinous xanthomatosis |
| Disorder | Clinical features | Associated features | Investigations | Disease modifying treatment available | Time critical |
|---|---|---|---|---|---|
| Herpes simplex encephalitis |
Seizure |
||||
| Transient epileptic amnesia | |||||
| Obstructive sleep apnoea |
Bilateral papilloedema Insomnia |
||||
| Hypercalcaemia |
Abdominal pain Depression |
||||
| Anti-LGI1 encephalitis |
Focal seizure Facio-brachial dystonic seizures |
Anti-CASPR2 encephalitis |
|||
| Anti-DPPX encephalitis |
Weight loss Diarrhoea Myoclonus Seizure Tremor Hyperekplexia Amnesia Hallucination |
||||
| Delirium |
Hallucination |
Calculation of an anticholinergic burden score may be helpful for identifying medications which could be causing or exacerbating cognitive impairment. A number of scores have been developed and published. Several online calculators for these scores, or combinations thereof, have been created. One such calculator which uses a combination of two validated score is available at: https://www.acbcalc.com/.
What is the optimal strategy for identifying medications contributing to cognitive dysfunction?