Disease modifying treatment available:
Time critical diagnosis and management:
Lateralising:
| Supercategory | |||||
|---|---|---|---|---|---|
| Hyperkinetic movement disorder |
| Disorder | Clinical features | Associated features | Investigations | Disease modifying treatment available | Time critical |
|---|---|---|---|---|---|
| Ischaemic stroke |
Ulcerative colitis Antiphospholipid syndrome |
||||
| Polycythaemia rubra vera |
Cerebral venous sinus thrombosis Pulmonary embolism Deep vein thrombosis Miscarriage |
||||
| Huntington's disease |
Dementia Parkinsonism Motor impersistence |
||||
| Hyperthyroidism |
Anxiety Diarrhoea |
Turner syndrome |
|||
| Dentatorubral-pallidoluysian atrophy |
Cerebellar ataxia Seizure Myoclonus Dementia |
||||
| Rheumatic chorea | |||||
| Wilson's disease |
Liver failure Acute liver failure |
||||
| Variant Creutzfeldt-Jakob disease |
| Laboratory Investigation | Result |
|---|
Pharmacological treatments for chorea are based on depleting dopaminergic signalling. Two main sets of targets have currently been identified:
1) Selective vesicular monoamine transporter 2 (VMAT2) inhibitors are used to reduce presynaptic dopamine.
2) D2 receptor antagonists are used to block the effects of dopamine at the post-synapse.