Angelman syndrome


Disease modifying treatment available:
Time critical diagnosis and management:
Lateralising:


Definition

None




Aetiology

Angelman syndrome is a genetic disorder characterised by loss of function variants affecting UBE3A which causes a ubiquitin ligase deficiency.

Associated genes

Gene
UBE3A Search ClinVar Search ClinGen



Clinical features


None

Angelman syndrome may cause the following:





Investigations


None

None


Laboratory Investigation Result

Treatment


None





Research


Open questions

None