Stiff-person syndrome

Disease modifying treatment available:
Time critical diagnosis and management:
Lateralising:

Definition

None



Aetiology

None



Clinical features


Paroxysmal spasms are usefully painful which can be helpful in the discrimination from other disorders.

Stiff-person syndrome may cause the following:




Investigations


Stiff-person syndrome has been associated with antibodies against glutamic acid decarboxylase and amphiphysin. EMG can demonstrate failure of muscle relaxation.

None


Laboratory Investigation Result

Treatment


None




Research


Open questions

None