Demyelinating peripheral neuropathy

Disease modifying treatment available:
Time critical diagnosis and management:
Lateralising:

Taxotomy

Aetiology

Immune checkpoint inhibitors have been implicated.
Vitamin E deficiency (though nutritional deficiencies generally cause axonal neuropathies)
Hydroxychloroquine and tacrolimus

Supercategory
Peripheral neuropathy
Disorder Clinical features Associated features Investigations Disease modifying treatment available Time critical
Guillain-Barre syndrome Peripheral neuropathy
Facial nerve palsy
Respiratory failure type 2
Acute polyneuropathy
Waldenstrom macroglobulinemia Peripheral neuropathy
Sjögren syndrome Facial nerve palsy
Dry eyes
Dry mouth
Longitudinally extensive myelitis
Peripheral neuropathy
Multifocal motor neuropathy with conduction block Weakness
Chronic inflammatory demyelinating polyneuropathy Acute polyneuropathy
CANOMAD Peripheral neuropathy
POEMS


Associated Disorders




Clinical features


Demyelinating peripheral neuropathy may cause the following:




Investigations


Blood tests that may be useful include: - Serum electrophoresis - Immunoglobulins - Anti-MAG - Paranodal antibodies - VEGF - Cold agglutinins - Genetics

LP typically shows albuminocytologic dissociation (i.e. protein is high but there are not many cells). The CSF white cell count is typically below 10 perr mm^3.


Laboratory Investigation Result